Thyroid-Induced Toxicity of Check-Point Inhibitors Immunotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer

Different strategies have been developed over time to improve the poor survival of patients affected by advanced NonSmall Cell Lung Cancer (NSCLC): radiotherapy, chemotherapy and molecular targeted therapies. Recently, in view of the hypothesis that the immunosuppression could be involved in the mechanism of carcinogenesis, by allowing tumor cells to evade immune-surveillance, new immunological drugs have been synthesized [1,2]. In particular, discovery of immune checkpoints, receptors expressed on T cells that regulate immune response, Abstract